Composition and method for treating hematologic cancers

A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C2-C4 alkyl este...

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Bibliographische Detailangaben
Hauptverfasser: JAIN, Mohit, WACHTER, Eric A, NARENDRAN, Aru, RODRIGUES, Dominic, ZHANG, Chunfen, SWIFT, Lucy, THAKUR, Satbir
Format: Patent
Sprache:eng
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Zusammenfassung:A method of treating a mammalian subject having hematologic, non-tumorous cancer cells is disclosed. The method comprises the steps of: (A) administering to such a mammalian subject a therapeutically effective amount of a halogenated xanthene, a pharmaceutically acceptable salt or a C2-C4 alkyl ester thereof as a first cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable aqueous medium. The mammalian subject is maintained for a period of time sufficient to induce death of hematologic, non-tumorous cancer cells. A contemplated administration is typically repeated, A contemplated treatment method can also be carried out in conjunction with administration to said mammalian subject of a second therapeutically effective amount of a second, differently-acting cancer cytotoxic agent dissolved or dispersed in a pharmaceutically acceptable medium, The second cancer cytotoxic agent can be a small molecule or an intact antibody or paratope-containing portion thereof.