Macrocyclic compounds and their use in the treatment of disease

The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The inven...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	ZHU, Xuefeng, BURSULAYA, Badry, JIANG, Songchun, WHITEHEAD, Lewis, WU, Baogen, YAN, Shanshan, NGUYEN, Truc Ngoc, OKRAM, Barun, AZIMIOARA, Mihai, MATHISON, Casey Jacob Nelson, NIKULIN, Victor Ivanovich, PHILLIPS, Dean Paul, PATEL, Sejal
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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