Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or del...

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Hauptverfasser: CONVERSO, Antonella, NANTERMET, Philippe, FORSTER, Ashley, WANG, Deping, MITCHELL, Helen J, SHIPE, William Daniel, WANG, Cheng, EL MARROUNI, Abdellatif, FRIE, Jessica L, HUNTER, David N, SHA, Deyou, KUDUK, Scott D
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creator CONVERSO, Antonella
NANTERMET, Philippe
FORSTER, Ashley
WANG, Deping
MITCHELL, Helen J
SHIPE, William Daniel
WANG, Cheng
EL MARROUNI, Abdellatif
FRIE, Jessica L
HUNTER, David N
SHA, Deyou
KUDUK, Scott D
description The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells
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