Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders

The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R

Bibliographische Detailangaben

Hauptverfasser:	LIU, Eugene Yuejin, DECHRISTOPHER, Brian Addison, GOLOSOV, Andrei Alexandrovich, MONOVICH, Lauren Gilchrist, YANG, Lihua, SANCHEZ, Carina Cristina, FLYER, Alec Nathanson, MAO, Justin Yik Ching, GROSCHE, Philipp, ZHENG, Rui, PATEL, Tajesh Jayprakash, BRINER, Karin, SU, Liansheng
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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