Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders
The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R
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| creator | LIU, Eugene Yuejin DECHRISTOPHER, Brian Addison GOLOSOV, Andrei Alexandrovich MONOVICH, Lauren Gilchrist YANG, Lihua SANCHEZ, Carina Cristina FLYER, Alec Nathanson MAO, Justin Yik Ching GROSCHE, Philipp ZHENG, Rui PATEL, Tajesh Jayprakash BRINER, Karin SU, Liansheng |
| description | The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R |
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YANG, Lihua ; SANCHEZ, Carina Cristina ; FLYER, Alec Nathanson ; MAO, Justin Yik Ching ; GROSCHE, Philipp ; ZHENG, Rui ; PATEL, Tajesh Jayprakash ; BRINER, Karin ; SU, Liansheng</creator><creatorcontrib>LIU, Eugene Yuejin ; DECHRISTOPHER, Brian Addison ; GOLOSOV, Andrei Alexandrovich ; MONOVICH, Lauren Gilchrist ; YANG, Lihua ; SANCHEZ, Carina Cristina ; FLYER, Alec Nathanson ; MAO, Justin Yik Ching ; GROSCHE, Philipp ; ZHENG, Rui ; PATEL, Tajesh Jayprakash ; BRINER, Karin ; SU, Liansheng</creatorcontrib><description>The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein R</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders |
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