PaCas9 nuclease

The present invention relates to biotechnology, molecular biology and medicine, and more precisely to a nuclease enzyme and use thereof. More particularly, the present invention relates to a PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic constr...

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Hauptverfasser: MADERA, Dmitriy Aleksandrovich, POBEGALOV, Georgii Evgenevich, VASILEVA, Aleksandra Andreevna, KARABELSKII, Aleksandr Vladimirovich, SELKOVA, Polina Anatolevna, SEVERINOV, Konstantin Viktorovich, FEDOROVA, Iana Vitalevna, SHMAKOV, Sergey Anatolevich, MOROZOV, Dmitry Valentinovich, ZYUBKO, Tatyana Igorevna, ARSENIEV, Anatolii Nikolaevich, SUTORMIN, Dmitrii Aleksandrovich, IVANOV, Roman Alekseevich
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to biotechnology, molecular biology and medicine, and more precisely to a nuclease enzyme and use thereof. More particularly, the present invention relates to a PaCas9 nuclease enzyme. The invention also relates to a nucleic acid encoding said nuclease, a genetic construct, an expression vector, a vector for delivery, which include said nucleic acid, a liposome incorporating said nuclease or nucleic acid encoding said nuclease, a method for producing nuclease, methods of delivery, as well as a host cell which includes a nucleic acid encoding said nuclease.