Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof

Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof

The invention provides a controlled release oral formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levadopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an ent...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HSU, Ann, DONG, Liang C, GUPTA, Suneel, DING, Amy
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides a controlled release oral formulation comprising (a) a controlled release component comprising core comprising levodopa and/or an ester of levadopa or salts thereof, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric coated polymer and (b) a decarboxylase inhibitor component.