Targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide

Targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide

The present invention relates to a melittin-anticancer drug conjugate in which melittin and an anticancer drug are conjugated, and to a method for preparing a melittin-anticancer drug conjugate by connecting melittin and an anticancer drug. A conjugate of the present invention is an anticancer mater...

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Hauptverfasser: JEONG, Jin-Hyun, KIM, Jeong-Dong, LEE, Chan-Ju, LEE, Do-Ha, BAE, Hyunsu
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator JEONG, Jin-Hyun
KIM, Jeong-Dong
LEE, Chan-Ju
LEE, Do-Ha
BAE, Hyunsu
description The present invention relates to a melittin-anticancer drug conjugate in which melittin and an anticancer drug are conjugated, and to a method for preparing a melittin-anticancer drug conjugate by connecting melittin and an anticancer drug. A conjugate of the present invention is an anticancer material for targeting M2-type tumor-associated TAMs and exhibits an excellent effect of selectively selecting M2-type tumor-associated TAMs, and thus can be used for a use of drug delivery for targeting M2-type tumor-associated macrophages.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide
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