Thiophene derivative and use thereof

The present invention relates to a thiophene derivative represented by general formula (I) (wherein each symbol is as defined in the description) or a salt thereof, which has an activity to prevent the production of TNF-α and an activity to prevent the proliferation of a hematological cancer cell, a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WATANABE, Mayumi, ISHII, Takafumi, YAMADA, Mitsuo, MATSUSHITA, Kenya, ANDO, Takashi, URABE, Kazunori, MIZUTANI, Yasuhiko, KANAOKA, Daiki, UEDA, Yasuyuki, TAKAHASHI, Jun, YOKOYAMA, Hironori
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a thiophene derivative represented by general formula (I) (wherein each symbol is as defined in the description) or a salt thereof, which has an activity to prevent the production of TNF-α and an activity to prevent the proliferation of a hematological cancer cell, and is useful for the treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis and hematological cancer.