BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF
This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the bindin...
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| creator | Ettinger, Catherine Herbst, Ronald Du, Qun Tsui, Ping Karnell, Jodi Chowdhury, Partha Naiman, Brian Michael Damschroder, Melissa Carter, Laura Drabic, Stacey Xiao, Xiaodong Varkey, Reena |
| description | This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof. |
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In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200910&DB=EPODOC&CC=AU&NR=2019202447B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200910&DB=EPODOC&CC=AU&NR=2019202447B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Ettinger, Catherine</creatorcontrib><creatorcontrib>Herbst, Ronald</creatorcontrib><creatorcontrib>Du, Qun</creatorcontrib><creatorcontrib>Tsui, Ping</creatorcontrib><creatorcontrib>Karnell, Jodi</creatorcontrib><creatorcontrib>Chowdhury, Partha</creatorcontrib><creatorcontrib>Naiman, Brian Michael</creatorcontrib><creatorcontrib>Damschroder, Melissa</creatorcontrib><creatorcontrib>Carter, Laura</creatorcontrib><creatorcontrib>Drabic, Stacey</creatorcontrib><creatorcontrib>Xiao, Xiaodong</creatorcontrib><creatorcontrib>Varkey, Reena</creatorcontrib><title>BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF</title><description>This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB18vRz8fRzV_D193F1DvVxDVYIDnB19nTzdFZw8w9S8PTRNTJUcPRzUQgNBsqFeLgGufq78TCwpiXmFKfyQmluBhU31xBnD93Ugvz41OKCxOTUvNSSeMdQIwNDSyMDIxMTcycnI2MilQEAmP8oag</recordid><startdate>20200910</startdate><enddate>20200910</enddate><creator>Ettinger, Catherine</creator><creator>Herbst, Ronald</creator><creator>Du, Qun</creator><creator>Tsui, Ping</creator><creator>Karnell, Jodi</creator><creator>Chowdhury, Partha</creator><creator>Naiman, Brian Michael</creator><creator>Damschroder, Melissa</creator><creator>Carter, Laura</creator><creator>Drabic, Stacey</creator><creator>Xiao, Xiaodong</creator><creator>Varkey, Reena</creator><scope>EVB</scope></search><sort><creationdate>20200910</creationdate><title>BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF</title><author>Ettinger, Catherine ; Herbst, Ronald ; Du, Qun ; Tsui, Ping ; Karnell, Jodi ; Chowdhury, Partha ; Naiman, Brian Michael ; Damschroder, Melissa ; Carter, Laura ; Drabic, Stacey ; Xiao, Xiaodong ; Varkey, Reena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2019202447BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Ettinger, Catherine</creatorcontrib><creatorcontrib>Herbst, Ronald</creatorcontrib><creatorcontrib>Du, Qun</creatorcontrib><creatorcontrib>Tsui, Ping</creatorcontrib><creatorcontrib>Karnell, Jodi</creatorcontrib><creatorcontrib>Chowdhury, Partha</creatorcontrib><creatorcontrib>Naiman, Brian Michael</creatorcontrib><creatorcontrib>Damschroder, Melissa</creatorcontrib><creatorcontrib>Carter, Laura</creatorcontrib><creatorcontrib>Drabic, Stacey</creatorcontrib><creatorcontrib>Xiao, Xiaodong</creatorcontrib><creatorcontrib>Varkey, Reena</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Ettinger, Catherine</au><au>Herbst, Ronald</au><au>Du, Qun</au><au>Tsui, Ping</au><au>Karnell, Jodi</au><au>Chowdhury, Partha</au><au>Naiman, Brian Michael</au><au>Damschroder, Melissa</au><au>Carter, Laura</au><au>Drabic, Stacey</au><au>Xiao, Xiaodong</au><au>Varkey, Reena</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF</title><date>2020-09-10</date><risdate>2020</risdate><abstract>This disclosure provides IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen binding fragments thereof. In certain aspects the anti-IL-21 antibodies and fragments thereof can be hybridoma-derived murine monoclonal antibodies, and humanized versions thereof. In certain aspects the binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof provided herein inhibit, suppress, or antagonize IL-21 activity. In addition, this disclosure provides compositions and methods for diagnosing and treating diseases or disorders, e.g., inflammatory, immune-mediated, or autoimmune diseases or disorders associated with IL-21 -mediated signal transduction. In a particular embodiment, the disclosure provides methods for treating or preventing Graft-versus-host disease (GVHD) using IL-21 binding molecules, e.g., anti-IL-21 antibodies and antigen-binding fragments thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| title | BINDING MOLECULES SPECIFIC FOR IL-21 AND USES THEREOF |
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