Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors

The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 5 enzyme. The invention also relates to methods of...

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Hauptverfasser: NAIR, Prathap Sreedharan, PALLE, Venkata P, GUDADE, Ganesh Bhausaheb, TRYAMBAKE, Mahadeo Bhaskar, KAMBOJ, Rajender Kumar, LAGAD, Dipak Raychand, GORE, Balasaheb Arjun, HAJARE, Anil Kashiram, SETHI, Sachin, KULKARNI, Sanjeev Anant, SINDKHEDKAR, Milind Dattatraya, KULKARNI, Chaitanya Prabhakar, PAWAR, Chetan Sanjay
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creator NAIR, Prathap Sreedharan
PALLE, Venkata P
GUDADE, Ganesh Bhausaheb
TRYAMBAKE, Mahadeo Bhaskar
KAMBOJ, Rajender Kumar
LAGAD, Dipak Raychand
GORE, Balasaheb Arjun
HAJARE, Anil Kashiram
SETHI, Sachin
KULKARNI, Sanjeev Anant
SINDKHEDKAR, Milind Dattatraya
KULKARNI, Chaitanya Prabhakar
PAWAR, Chetan Sanjay
description The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors
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