Substituted pyrrolopyrimidine JAK inhibitors and methods of making and using the same

Substituted pyrrolopyrimidine JAK inhibitors and methods of making and using the same

The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, al...

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Hauptverfasser: JACOBSEN, Eric Jon, ANDERSON, David Randolph, HOCKERMAN, Susan Landis, BLINN, James Robert
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator JACOBSEN, Eric Jon
ANDERSON, David Randolph
HOCKERMAN, Susan Landis
BLINN, James Robert
description The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.
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METALLURGY
ORGANIC CHEMISTRY
title Substituted pyrrolopyrimidine JAK inhibitors and methods of making and using the same
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