Pharmaceutical nanoparticles showing improved mucosal transport

Abstract Particles, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. The pharmaceutica...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Hongming, Enlow, Elizabeth M, Popov, Alexey
Format: Patent
Sprache:eng
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Zusammenfassung:Abstract Particles, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. The pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye. 28'Q Fig. I .1Tn R I I TTI-fPPTCP TTI FP1