Pyrimidine tricyclic enone derivatives for inhibition of RORgamma and other uses

Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-...

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Hauptverfasser:	Kornberg, Brian, Sheldon, Zachary S, Jiang, Xin, Hotema, Martha R, Lee, Chitase, Bender, Christopher F, Bolton, Gary, Caprathe, Bradley William, Visnick, Melean
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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