Pyrimidine tricyclic enone derivatives for inhibition of RORgamma and other uses
Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-...
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| creator | Kornberg, Brian Sheldon, Zachary S Jiang, Xin Hotema, Martha R Lee, Chitase Bender, Christopher F Bolton, Gary Caprathe, Bradley William Visnick, Melean |
| description | Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders. |
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Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220217&DB=EPODOC&CC=AU&NR=2017377852B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220217&DB=EPODOC&CC=AU&NR=2017377852B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kornberg, Brian</creatorcontrib><creatorcontrib>Sheldon, Zachary S</creatorcontrib><creatorcontrib>Jiang, Xin</creatorcontrib><creatorcontrib>Hotema, Martha R</creatorcontrib><creatorcontrib>Lee, Chitase</creatorcontrib><creatorcontrib>Bender, Christopher F</creatorcontrib><creatorcontrib>Bolton, Gary</creatorcontrib><creatorcontrib>Caprathe, Bradley William</creatorcontrib><creatorcontrib>Visnick, Melean</creatorcontrib><title>Pyrimidine tricyclic enone derivatives for inhibition of RORgamma and other uses</title><description>Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyrimidine tricyclic enone derivatives for inhibition of RORgamma and other uses |
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