Specific binding proteins and uses thereof
SPECIFIC BINDING PROTEINS AND USES THEREOF The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by...
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| creator | COLLINS, Peter MARK, George OLD, Lloyd J NICE, Edouard Collins BURGESS, Antony Wilks PANOUSIS, Con JUNGBLUTH, Achim SCOTT, Andrew Mark RITTER, Gerd CAVENEE, Webster K JONHS, Terrance Grant HUANG, Huei-Jen Su STOCKERT, Elizabeth RENNER, Christoph MURRAY, Anne |
| description | SPECIFIC BINDING PROTEINS AND USES THEREOF The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. |
| format | Patent |
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In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TESTING</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180118&DB=EPODOC&CC=AU&NR=2017276184A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180118&DB=EPODOC&CC=AU&NR=2017276184A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>COLLINS, Peter</creatorcontrib><creatorcontrib>MARK, George</creatorcontrib><creatorcontrib>OLD, Lloyd J</creatorcontrib><creatorcontrib>NICE, Edouard Collins</creatorcontrib><creatorcontrib>BURGESS, Antony Wilks</creatorcontrib><creatorcontrib>PANOUSIS, Con</creatorcontrib><creatorcontrib>JUNGBLUTH, Achim</creatorcontrib><creatorcontrib>SCOTT, Andrew Mark</creatorcontrib><creatorcontrib>RITTER, Gerd</creatorcontrib><creatorcontrib>CAVENEE, Webster K</creatorcontrib><creatorcontrib>JONHS, Terrance Grant</creatorcontrib><creatorcontrib>HUANG, Huei-Jen Su</creatorcontrib><creatorcontrib>STOCKERT, Elizabeth</creatorcontrib><creatorcontrib>RENNER, Christoph</creatorcontrib><creatorcontrib>MURRAY, Anne</creatorcontrib><title>Specific binding proteins and uses thereof</title><description>SPECIFIC BINDING PROTEINS AND USES THEREOF The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. 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In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING |
| title | Specific binding proteins and uses thereof |
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