c-Met modulators and methods of use

C:lNRPonIbimCOJAMUII7f42_l.DOC-2627/2 0 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides...

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Hauptverfasser:	Huynh, Tai Phat, Takeuchi, Craig Stacy, Wang, Yong, Jammalamadaka, Vasu, Chan, Diva Sze-Ming, Leahy, James William, Parks, Jason Jevious, Dalrymple, Lisa Esther, Mann, Grace, Mann, Larry W, Xu, Wei, Chen, Jeff, Forsyth, Timothy Patrick, Khoury, Richard George, Nuss, John M, Bannen, Lynne Canne, Mac, Morrison B
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	C:lNRPonIbimCOJAMUII7f42_l.DOC-2627/2 0 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. 10 The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.