Method for preparing deuterated imidazole diketone compound
Disclosed is a method for preparing a deuterated imidazole diketone compound, comprising the following steps: (1) using a compound of formula (I) and a compound of formula (II) as raw materials to obtain a compound of formula (III) by means of a substitution reaction; (2) carrying out an esterificat...
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creator | Chen, Yuanwei Kuang, Tongtao Du, Wu Geng, Xi |
description | Disclosed is a method for preparing a deuterated imidazole diketone compound, comprising the following steps: (1) using a compound of formula (I) and a compound of formula (II) as raw materials to obtain a compound of formula (III) by means of a substitution reaction; (2) carrying out an esterification reaction of carboxyl groups in the compound of formula (III) to obtain a compound of formula (IV); (3) carrying out a cycloaddition reaction of the compound of formula (IV) and a compound of formula (V) to obtain a compound of formula (VI); (4) carrying out a deesterification reaction of the compound of formula (VI) to obtain a compound of formula (VII); and (5) using the compound of formula (VII) and a compound of formula (VIII) as raw materials, by an amide-forming condensation reaction, to obtain the deuterated imidazole diketone compound as represented by formula (IX). As compared to the existing methods, the method of the present invention is safer, consumes less solvent, and reduces waste thereby minimizing environmental impacts, shortens the production cycle, and increases throughput and total yield, and therefore has broad market prospects. |
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As compared to the existing methods, the method of the present invention is safer, consumes less solvent, and reduces waste thereby minimizing environmental impacts, shortens the production cycle, and increases throughput and total yield, and therefore has broad market prospects.</description><language>eng</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190606&DB=EPODOC&CC=AU&NR=2016426847A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190606&DB=EPODOC&CC=AU&NR=2016426847A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Chen, Yuanwei</creatorcontrib><creatorcontrib>Kuang, Tongtao</creatorcontrib><creatorcontrib>Du, Wu</creatorcontrib><creatorcontrib>Geng, Xi</creatorcontrib><title>Method for preparing deuterated imidazole diketone compound</title><description>Disclosed is a method for preparing a deuterated imidazole diketone compound, comprising the following steps: (1) using a compound of formula (I) and a compound of formula (II) as raw materials to obtain a compound of formula (III) by means of a substitution reaction; (2) carrying out an esterification reaction of carboxyl groups in the compound of formula (III) to obtain a compound of formula (IV); (3) carrying out a cycloaddition reaction of the compound of formula (IV) and a compound of formula (V) to obtain a compound of formula (VI); (4) carrying out a deesterification reaction of the compound of formula (VI) to obtain a compound of formula (VII); and (5) using the compound of formula (VII) and a compound of formula (VIII) as raw materials, by an amide-forming condensation reaction, to obtain the deuterated imidazole diketone compound as represented by formula (IX). As compared to the existing methods, the method of the present invention is safer, consumes less solvent, and reduces waste thereby minimizing environmental impacts, shortens the production cycle, and increases throughput and total yield, and therefore has broad market prospects.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD2TS3JyE9RSMsvUigoSi1ILMrMS1dISS0tSS1KLElNUcjMzUxJrMrPSVVIycxOLcnPS1VIzs8tyC_NS-FhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGOoUYGhmYmRmYWJuaOhsbEqQIAo4Mwzw</recordid><startdate>20190606</startdate><enddate>20190606</enddate><creator>Chen, Yuanwei</creator><creator>Kuang, Tongtao</creator><creator>Du, Wu</creator><creator>Geng, Xi</creator><scope>EVB</scope></search><sort><creationdate>20190606</creationdate><title>Method for preparing deuterated imidazole diketone compound</title><author>Chen, Yuanwei ; Kuang, Tongtao ; Du, Wu ; Geng, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2016426847A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2019</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yuanwei</creatorcontrib><creatorcontrib>Kuang, Tongtao</creatorcontrib><creatorcontrib>Du, Wu</creatorcontrib><creatorcontrib>Geng, Xi</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chen, Yuanwei</au><au>Kuang, Tongtao</au><au>Du, Wu</au><au>Geng, Xi</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for preparing deuterated imidazole diketone compound</title><date>2019-06-06</date><risdate>2019</risdate><abstract>Disclosed is a method for preparing a deuterated imidazole diketone compound, comprising the following steps: (1) using a compound of formula (I) and a compound of formula (II) as raw materials to obtain a compound of formula (III) by means of a substitution reaction; (2) carrying out an esterification reaction of carboxyl groups in the compound of formula (III) to obtain a compound of formula (IV); (3) carrying out a cycloaddition reaction of the compound of formula (IV) and a compound of formula (V) to obtain a compound of formula (VI); (4) carrying out a deesterification reaction of the compound of formula (VI) to obtain a compound of formula (VII); and (5) using the compound of formula (VII) and a compound of formula (VIII) as raw materials, by an amide-forming condensation reaction, to obtain the deuterated imidazole diketone compound as represented by formula (IX). As compared to the existing methods, the method of the present invention is safer, consumes less solvent, and reduces waste thereby minimizing environmental impacts, shortens the production cycle, and increases throughput and total yield, and therefore has broad market prospects.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
title | Method for preparing deuterated imidazole diketone compound |
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