Multi-lineage hematopoietic precursor cell production by genetic programming

The present disclosure generally regards methods and compositions for providing multi-lineage hematopoietic precursor cells from pluripotent stem cells (PSCs). The PSCs comprise an expression construct encoding an ETS/ERG gene, GATA2 and HOXA9. Also provided are methods for providing hematopoietic s...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Junying, Rajesh, Deepika, Sasaki, Jeffrey, Burton, Sarah A, Vodyanyk, Maksym A
Format: Patent
Sprache:eng
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