Capped and uncapped antibody cysteines, and their use in antibody-drug conjugation

An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs)...

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Bibliographische Detailangaben
Hauptverfasser:	Somers, Will, Letendre, Leo Joseph, He, Tao, Kriz, Ronald William, Zhong, Xiaotian, Wang, Wenge, Prashad, Amarnauth Shastrie
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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