Glycopyrronium fatty acid salts and methods of making same

Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred em...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Liu, Xuejun Karl, Mobele, Bingidimi Itute, Puppali, Satish Goud, Rich, Steven A, Eisenreich, Emerich
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	Liu, Xuejun Karl Mobele, Bingidimi Itute Puppali, Satish Goud Rich, Steven A Eisenreich, Emerich
description	Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU2016279798BB2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU2016279798BB2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU2016279798BB23</originalsourceid><addsrcrecordid>eNrjZLByz6lMzi-oLCrKz8sszVVISywpqVRITM5MUShOzCkpVkjMS1HITS3JyE8pVshPU8hNzM7MSwfK5abyMLCmJeYUp_JCaW4GFTfXEGcP3dSC_PjU4oLE5NS81JJ4x1AjA0MzI3NLc0sLJycjYyKVAQCl9DCN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Glycopyrronium fatty acid salts and methods of making same</title><source>esp@cenet</source><creator>Liu, Xuejun Karl ; Mobele, Bingidimi Itute ; Puppali, Satish Goud ; Rich, Steven A ; Eisenreich, Emerich</creator><creatorcontrib>Liu, Xuejun Karl ; Mobele, Bingidimi Itute ; Puppali, Satish Goud ; Rich, Steven A ; Eisenreich, Emerich</creatorcontrib><description>Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210708&DB=EPODOC&CC=AU&NR=2016279798B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210708&DB=EPODOC&CC=AU&NR=2016279798B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Liu, Xuejun Karl</creatorcontrib><creatorcontrib>Mobele, Bingidimi Itute</creatorcontrib><creatorcontrib>Puppali, Satish Goud</creatorcontrib><creatorcontrib>Rich, Steven A</creatorcontrib><creatorcontrib>Eisenreich, Emerich</creatorcontrib><title>Glycopyrronium fatty acid salts and methods of making same</title><description>Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLByz6lMzi-oLCrKz8sszVVISywpqVRITM5MUShOzCkpVkjMS1HITS3JyE8pVshPU8hNzM7MSwfK5abyMLCmJeYUp_JCaW4GFTfXEGcP3dSC_PjU4oLE5NS81JJ4x1AjA0MzI3NLc0sLJycjYyKVAQCl9DCN</recordid><startdate>20210708</startdate><enddate>20210708</enddate><creator>Liu, Xuejun Karl</creator><creator>Mobele, Bingidimi Itute</creator><creator>Puppali, Satish Goud</creator><creator>Rich, Steven A</creator><creator>Eisenreich, Emerich</creator><scope>EVB</scope></search><sort><creationdate>20210708</creationdate><title>Glycopyrronium fatty acid salts and methods of making same</title><author>Liu, Xuejun Karl ; Mobele, Bingidimi Itute ; Puppali, Satish Goud ; Rich, Steven A ; Eisenreich, Emerich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2016279798BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xuejun Karl</creatorcontrib><creatorcontrib>Mobele, Bingidimi Itute</creatorcontrib><creatorcontrib>Puppali, Satish Goud</creatorcontrib><creatorcontrib>Rich, Steven A</creatorcontrib><creatorcontrib>Eisenreich, Emerich</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Xuejun Karl</au><au>Mobele, Bingidimi Itute</au><au>Puppali, Satish Goud</au><au>Rich, Steven A</au><au>Eisenreich, Emerich</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Glycopyrronium fatty acid salts and methods of making same</title><date>2021-07-08</date><risdate>2021</risdate><abstract>Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_AU2016279798BB2
source	esp@cenet
subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Glycopyrronium fatty acid salts and methods of making same
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T12%3A25%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Liu,%20Xuejun%20Karl&rft.date=2021-07-08&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2016279798BB2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true