Inhibitors of influenza viruses replication
Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amou...
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| creator | Wannamaker, M. Woods Gu, Wenxin Deng, Hongbo Wang, Tiansheng Court, John J Ledeboer, Mark W Lin, Chao Ledford, Brian Bandarage, Upul K Drutu, Ioana Duffy, John P Gao, Huai Jacobs, Dylan H Farmer, Luc Kwong, Ann Dak-Yee Bethiel, Randy S Kennedy, Joseph M Jones, Steven Clark, Michael P Charifson, Paul Jiang, Min Perola, Emanuele Germann, Ursula A Maltais, Francois Zhou, Yi Byrn, Randal Salituro, Francesco G |
| description | Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle. |
| format | Patent |
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Woods ; Gu, Wenxin ; Deng, Hongbo ; Wang, Tiansheng ; Court, John J ; Ledeboer, Mark W ; Lin, Chao ; Ledford, Brian ; Bandarage, Upul K ; Drutu, Ioana ; Duffy, John P ; Gao, Huai ; Jacobs, Dylan H ; Farmer, Luc ; Kwong, Ann Dak-Yee ; Bethiel, Randy S ; Kennedy, Joseph M ; Jones, Steven ; Clark, Michael P ; Charifson, Paul ; Jiang, Min ; Perola, Emanuele ; Germann, Ursula A ; Maltais, Francois ; Zhou, Yi ; Byrn, Randal ; Salituro, Francesco G</creator><creatorcontrib>Wannamaker, M. Woods ; Gu, Wenxin ; Deng, Hongbo ; Wang, Tiansheng ; Court, John J ; Ledeboer, Mark W ; Lin, Chao ; Ledford, Brian ; Bandarage, Upul K ; Drutu, Ioana ; Duffy, John P ; Gao, Huai ; Jacobs, Dylan H ; Farmer, Luc ; Kwong, Ann Dak-Yee ; Bethiel, Randy S ; Kennedy, Joseph M ; Jones, Steven ; Clark, Michael P ; Charifson, Paul ; Jiang, Min ; Perola, Emanuele ; Germann, Ursula A ; Maltais, Francois ; Zhou, Yi ; Byrn, Randal ; Salituro, Francesco G</creatorcontrib><description>Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180201&DB=EPODOC&CC=AU&NR=2016204286B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180201&DB=EPODOC&CC=AU&NR=2016204286B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Wannamaker, M. Woods</creatorcontrib><creatorcontrib>Gu, Wenxin</creatorcontrib><creatorcontrib>Deng, Hongbo</creatorcontrib><creatorcontrib>Wang, Tiansheng</creatorcontrib><creatorcontrib>Court, John J</creatorcontrib><creatorcontrib>Ledeboer, Mark W</creatorcontrib><creatorcontrib>Lin, Chao</creatorcontrib><creatorcontrib>Ledford, Brian</creatorcontrib><creatorcontrib>Bandarage, Upul K</creatorcontrib><creatorcontrib>Drutu, Ioana</creatorcontrib><creatorcontrib>Duffy, John P</creatorcontrib><creatorcontrib>Gao, Huai</creatorcontrib><creatorcontrib>Jacobs, Dylan H</creatorcontrib><creatorcontrib>Farmer, Luc</creatorcontrib><creatorcontrib>Kwong, Ann Dak-Yee</creatorcontrib><creatorcontrib>Bethiel, Randy S</creatorcontrib><creatorcontrib>Kennedy, Joseph M</creatorcontrib><creatorcontrib>Jones, Steven</creatorcontrib><creatorcontrib>Clark, Michael P</creatorcontrib><creatorcontrib>Charifson, Paul</creatorcontrib><creatorcontrib>Jiang, Min</creatorcontrib><creatorcontrib>Perola, Emanuele</creatorcontrib><creatorcontrib>Germann, Ursula A</creatorcontrib><creatorcontrib>Maltais, Francois</creatorcontrib><creatorcontrib>Zhou, Yi</creatorcontrib><creatorcontrib>Byrn, Randal</creatorcontrib><creatorcontrib>Salituro, Francesco G</creatorcontrib><title>Inhibitors of influenza viruses replication</title><description>Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND2zMvITMosyS8qVshPU8jMS8spTc2rSlQoyywqLU4tVihKLcjJTE4syczP42FgTUvMKU7lhdLcDCpuriHOHrqpBfnxqcUFicmpeakl8Y6hRgaGZkYGJkYWZk5ORsZEKgMAl8crUQ</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Wannamaker, M. 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Woods ; Gu, Wenxin ; Deng, Hongbo ; Wang, Tiansheng ; Court, John J ; Ledeboer, Mark W ; Lin, Chao ; Ledford, Brian ; Bandarage, Upul K ; Drutu, Ioana ; Duffy, John P ; Gao, Huai ; Jacobs, Dylan H ; Farmer, Luc ; Kwong, Ann Dak-Yee ; Bethiel, Randy S ; Kennedy, Joseph M ; Jones, Steven ; Clark, Michael P ; Charifson, Paul ; Jiang, Min ; Perola, Emanuele ; Germann, Ursula A ; Maltais, Francois ; Zhou, Yi ; Byrn, Randal ; Salituro, Francesco G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2016204286BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2018</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Wannamaker, M. 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Woods</au><au>Gu, Wenxin</au><au>Deng, Hongbo</au><au>Wang, Tiansheng</au><au>Court, John J</au><au>Ledeboer, Mark W</au><au>Lin, Chao</au><au>Ledford, Brian</au><au>Bandarage, Upul K</au><au>Drutu, Ioana</au><au>Duffy, John P</au><au>Gao, Huai</au><au>Jacobs, Dylan H</au><au>Farmer, Luc</au><au>Kwong, Ann Dak-Yee</au><au>Bethiel, Randy S</au><au>Kennedy, Joseph M</au><au>Jones, Steven</au><au>Clark, Michael P</au><au>Charifson, Paul</au><au>Jiang, Min</au><au>Perola, Emanuele</au><au>Germann, Ursula A</au><au>Maltais, Francois</au><au>Zhou, Yi</au><au>Byrn, Randal</au><au>Salituro, Francesco G</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Inhibitors of influenza viruses replication</title><date>2018-02-01</date><risdate>2018</risdate><abstract>Abstract Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Inhibitors of influenza viruses replication |
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