AMORPHOUS DRUG TRANSDERMAL SYSTEMS, MANUFACTURING METHODS, AND STABILIZATION

AMORPHOUS DRUG TRANSDERMAL SYSTEMS, MANUFACTURING METHODS, AND STABILIZATION

The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a meth...

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Hauptverfasser: BESTE, RUSSELL D, TANG, JIANSHENG, MILLER II, KENNETH J, DEVERICH, JOSEPH M
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator BESTE, RUSSELL D
TANG, JIANSHENG
MILLER II, KENNETH J
DEVERICH, JOSEPH M
description The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title AMORPHOUS DRUG TRANSDERMAL SYSTEMS, MANUFACTURING METHODS, AND STABILIZATION
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