GLP-1 receptor modulators
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as G...
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creator | Huang, Liming Knaggs, Michael Meghani, Premji Novak, Andrew Fowler, Thomas Martinborough, Esther Yeager, Adam R Glynn, Daniel Tamiya, Junko Moorjani, Manisha Mills, Mark Brahmachary, Enugurthi Boehm, Marcus F |
description | Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "^^^" represents either or both the R and S form of the compound) (I) where A, B, C, Y |
format | Patent |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
title | GLP-1 receptor modulators |
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