GLP-1 receptor modulators

Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as G...

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Hauptverfasser: Huang, Liming, Knaggs, Michael, Meghani, Premji, Novak, Andrew, Fowler, Thomas, Martinborough, Esther, Yeager, Adam R, Glynn, Daniel, Tamiya, Junko, Moorjani, Manisha, Mills, Mark, Brahmachary, Enugurthi, Boehm, Marcus F
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creator Huang, Liming
Knaggs, Michael
Meghani, Premji
Novak, Andrew
Fowler, Thomas
Martinborough, Esther
Yeager, Adam R
Glynn, Daniel
Tamiya, Junko
Moorjani, Manisha
Mills, Mark
Brahmachary, Enugurthi
Boehm, Marcus F
description Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "^^^" represents either or both the R and S form of the compound) (I) where A, B, C, Y
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title GLP-1 receptor modulators
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