Novel carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1

The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.

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Hauptverfasser: Partridge, Katherine Marie, York, Jeremy Schulenburg, Kuklish, Steven Lee, Fisher, Matthew Joseph
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creator Partridge, Katherine Marie
York, Jeremy Schulenburg
Kuklish, Steven Lee
Fisher, Matthew Joseph
description The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Novel carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1
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