Assays and methods for selecting a treatment regimen for a subject with depression

Assays and methods for selecting a treatment regimen for a subject with depression

The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide poly...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KOCH JR., HAROLD O, KRONLAGE, DAVID, FAVA, MAURIZIO, PAPAKOSTAS, GEORGE
Format: Patent
Sprache:eng
Schlagworte:
CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
PHYSICS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator KOCH JR., HAROLD O
KRONLAGE, DAVID
FAVA, MAURIZIO
PAPAKOSTAS, GEORGE
description The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU2014248949A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU2014248949A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU2014248949A13</originalsourceid><addsrcrecordid>eNqNyjEKwkAQRuE0FqLeYcBaMHELUy6iWIvWYcz-SVaS3bAzIt7eIB7A6r3im2cXK8JvIQ6OBmgXnVATEwl61OpDS0yawDogKCW0fpqvYJLn_TEhenntyGFMEPExLLNZw71g9esiW5-O18N5gzFWkJFrBGhlb8U2N4XZl6a0-e4_9QHoPzjr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Assays and methods for selecting a treatment regimen for a subject with depression</title><source>esp@cenet</source><creator>KOCH JR., HAROLD O ; KRONLAGE, DAVID ; FAVA, MAURIZIO ; PAPAKOSTAS, GEORGE</creator><creatorcontrib>KOCH JR., HAROLD O ; KRONLAGE, DAVID ; FAVA, MAURIZIO ; PAPAKOSTAS, GEORGE</creatorcontrib><description>The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.</description><language>eng</language><subject>CALCULATING ; COMPUTING ; COUNTING ; ELECTRIC DIGITAL DATA PROCESSING ; PHYSICS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150910&amp;DB=EPODOC&amp;CC=AU&amp;NR=2014248949A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150910&amp;DB=EPODOC&amp;CC=AU&amp;NR=2014248949A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KOCH JR., HAROLD O</creatorcontrib><creatorcontrib>KRONLAGE, DAVID</creatorcontrib><creatorcontrib>FAVA, MAURIZIO</creatorcontrib><creatorcontrib>PAPAKOSTAS, GEORGE</creatorcontrib><title>Assays and methods for selecting a treatment regimen for a subject with depression</title><description>The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.</description><subject>CALCULATING</subject><subject>COMPUTING</subject><subject>COUNTING</subject><subject>ELECTRIC DIGITAL DATA PROCESSING</subject><subject>PHYSICS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKwkAQRuE0FqLeYcBaMHELUy6iWIvWYcz-SVaS3bAzIt7eIB7A6r3im2cXK8JvIQ6OBmgXnVATEwl61OpDS0yawDogKCW0fpqvYJLn_TEhenntyGFMEPExLLNZw71g9esiW5-O18N5gzFWkJFrBGhlb8U2N4XZl6a0-e4_9QHoPzjr</recordid><startdate>20150910</startdate><enddate>20150910</enddate><creator>KOCH JR., HAROLD O</creator><creator>KRONLAGE, DAVID</creator><creator>FAVA, MAURIZIO</creator><creator>PAPAKOSTAS, GEORGE</creator><scope>EVB</scope></search><sort><creationdate>20150910</creationdate><title>Assays and methods for selecting a treatment regimen for a subject with depression</title><author>KOCH JR., HAROLD O ; KRONLAGE, DAVID ; FAVA, MAURIZIO ; PAPAKOSTAS, GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2014248949A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CALCULATING</topic><topic>COMPUTING</topic><topic>COUNTING</topic><topic>ELECTRIC DIGITAL DATA PROCESSING</topic><topic>PHYSICS</topic><toplevel>online_resources</toplevel><creatorcontrib>KOCH JR., HAROLD O</creatorcontrib><creatorcontrib>KRONLAGE, DAVID</creatorcontrib><creatorcontrib>FAVA, MAURIZIO</creatorcontrib><creatorcontrib>PAPAKOSTAS, GEORGE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KOCH JR., HAROLD O</au><au>KRONLAGE, DAVID</au><au>FAVA, MAURIZIO</au><au>PAPAKOSTAS, GEORGE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Assays and methods for selecting a treatment regimen for a subject with depression</title><date>2015-09-10</date><risdate>2015</risdate><abstract>The present invention provides assays, methods and compositions for selecting a treatment regimen for a patient having depression or at risk for depression and/or treating at least one symptom of depression in the subject, based on the recognition that specific combinations of single nucleotide polymorphisms (SNPs) are associated with a therapeutic response to a folate-comprising compound. Provided herein are also methods for improving the effectiveness of an antidepressant drug administered to a subject with depression or at risk for depression by administering an adjunctive therapy of a folate-comprising compound to the subject if the subject carries a specific combination of SNPs that are predictive of a therapeutic response. Furthermore, provided herein are compositions of the folate-comprising compound.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_epo_espacenet_AU2014248949A1
source esp@cenet
subjects CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
PHYSICS
title Assays and methods for selecting a treatment regimen for a subject with depression
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T09%3A43%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=KOCH%20JR.,%20HAROLD%20O&rft.date=2015-09-10&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2014248949A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true