Pegylated Aß Fab
PEGYLATED AQ FAB Abstract A pharmaceutical composition suitable for subcutaneous administration is described. The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable reg...
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| creator | CHOW, CHI-KIN HANSEN, RYAN JOHN LU, JIRONG KUCHIBHOTIA, UMA MCDONNELL, PETER COLON BALES, KELLY RENEE BUMOL, THOMAS FRANK DEMATTOS, RONALD BRADLEY |
| description | PEGYLATED AQ FAB Abstract A pharmaceutical composition suitable for subcutaneous administration is described. The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable region of SEQ ID NO: 1 and a heavy chain variable region of SEQ ID NO: 2, and wherein a polyethylene glycol molecule is covalently attached to a CDR of the heavy chain variable region of the antibody fragment. Methods of treatment employing such compositions are also described, as is the use of such compositions for the preparation of a medicament for such treatments. |
| format | Patent |
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The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable region of SEQ ID NO: 1 and a heavy chain variable region of SEQ ID NO: 2, and wherein a polyethylene glycol molecule is covalently attached to a CDR of the heavy chain variable region of the antibody fragment. Methods of treatment employing such compositions are also described, as is the use of such compositions for the preparation of a medicament for such treatments.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131010&DB=EPODOC&CC=AU&NR=2013231065A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131010&DB=EPODOC&CC=AU&NR=2013231065A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOW, CHI-KIN</creatorcontrib><creatorcontrib>HANSEN, RYAN JOHN</creatorcontrib><creatorcontrib>LU, JIRONG</creatorcontrib><creatorcontrib>KUCHIBHOTIA, UMA</creatorcontrib><creatorcontrib>MCDONNELL, PETER COLON</creatorcontrib><creatorcontrib>BALES, KELLY RENEE</creatorcontrib><creatorcontrib>BUMOL, THOMAS FRANK</creatorcontrib><creatorcontrib>DEMATTOS, RONALD BRADLEY</creatorcontrib><title>Pegylated Aß Fab</title><description>PEGYLATED AQ FAB Abstract A pharmaceutical composition suitable for subcutaneous administration is described. The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable region of SEQ ID NO: 1 and a heavy chain variable region of SEQ ID NO: 2, and wherein a polyethylene glycol molecule is covalently attached to a CDR of the heavy chain variable region of the antibody fragment. Methods of treatment employing such compositions are also described, as is the use of such compositions for the preparation of a medicament for such treatments.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAMSE2vzEksSU1RcDw8X8EtMYmHgTUtMac4lRdKczMou7mGOHvophbkx6cWFyQmp-allsQ7hhoZGBobGRsamJk6GhoTpwoAQrAgQQ</recordid><startdate>20131010</startdate><enddate>20131010</enddate><creator>CHOW, CHI-KIN</creator><creator>HANSEN, RYAN JOHN</creator><creator>LU, JIRONG</creator><creator>KUCHIBHOTIA, UMA</creator><creator>MCDONNELL, PETER COLON</creator><creator>BALES, KELLY RENEE</creator><creator>BUMOL, THOMAS FRANK</creator><creator>DEMATTOS, RONALD BRADLEY</creator><scope>EVB</scope></search><sort><creationdate>20131010</creationdate><title>Pegylated Aß Fab</title><author>CHOW, CHI-KIN ; HANSEN, RYAN JOHN ; LU, JIRONG ; KUCHIBHOTIA, UMA ; MCDONNELL, PETER COLON ; BALES, KELLY RENEE ; BUMOL, THOMAS FRANK ; DEMATTOS, RONALD BRADLEY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2013231065A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2013</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHOW, CHI-KIN</creatorcontrib><creatorcontrib>HANSEN, RYAN JOHN</creatorcontrib><creatorcontrib>LU, JIRONG</creatorcontrib><creatorcontrib>KUCHIBHOTIA, UMA</creatorcontrib><creatorcontrib>MCDONNELL, PETER COLON</creatorcontrib><creatorcontrib>BALES, KELLY RENEE</creatorcontrib><creatorcontrib>BUMOL, THOMAS FRANK</creatorcontrib><creatorcontrib>DEMATTOS, RONALD BRADLEY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHOW, CHI-KIN</au><au>HANSEN, RYAN JOHN</au><au>LU, JIRONG</au><au>KUCHIBHOTIA, UMA</au><au>MCDONNELL, PETER COLON</au><au>BALES, KELLY RENEE</au><au>BUMOL, THOMAS FRANK</au><au>DEMATTOS, RONALD BRADLEY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pegylated Aß Fab</title><date>2013-10-10</date><risdate>2013</risdate><abstract>PEGYLATED AQ FAB Abstract A pharmaceutical composition suitable for subcutaneous administration is described. The composition comprises an antibody fragment that specifically binds human AP peptide between amino acid positions 13-28, wherein the antibody fragment comprises a light chain variable region of SEQ ID NO: 1 and a heavy chain variable region of SEQ ID NO: 2, and wherein a polyethylene glycol molecule is covalently attached to a CDR of the heavy chain variable region of the antibody fragment. Methods of treatment employing such compositions are also described, as is the use of such compositions for the preparation of a medicament for such treatments.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Pegylated Aß Fab |
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