2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composit...

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Hauptverfasser: Lee, Hyun Jung, Ahn, Jaeseung, Shin, Dong Chul, Kim, Jae-Sun, Jung, Hoechul, Kim, Yong-Hyuk, Lee, Bong-yong, Lee, Ju Young, Kim, Hun-Taek, Ryu, Keun-Ho, Kang, Sang-hwan, Park, Euisun, Shin, Young Ah, Ryu, Je Ho
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator Lee, Hyun Jung
Ahn, Jaeseung
Shin, Dong Chul
Kim, Jae-Sun
Jung, Hoechul
Kim, Yong-Hyuk
Lee, Bong-yong
Lee, Ju Young
Kim, Hun-Taek
Ryu, Keun-Ho
Kang, Sang-hwan
Park, Euisun
Shin, Young Ah
Ryu, Je Ho
description The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4); a pharmaceutical composition comprising same as an active ingredient; and a use of the 2-pyridyl substituted imidazole derivative for the manufacture of a medicament for preventing or treating a disease mediated by ALK5 and/or ALK4 receptors in a mammal.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
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