System and methods for driverless operation of USB device

Systems and methods of re-enumerating peripheral devices operatively connected to a computer system are provided. In one example, a system is configured to disable an existing connection between an operating system and a peripheral device established through a device driver by re-describing the peripheral device to the OS. In another example, the system can be further configured to execute operation(s) on the peripheral device without new driver installation using communication channels native to the OS. Once the operation(s) are complete, the system can be configured to restore the existing connection.