Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene

Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Al...

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Hauptverfasser: VAN DEN BOSCH, SANDRA MARTINA, VERSTEEGEN, RONNY MATHIEU, ROSSIN, RAFFAELLA, ROBILLARD, MARC STEFAN, LUB, JOHAN
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator VAN DEN BOSCH, SANDRA MARTINA
VERSTEEGEN, RONNY MATHIEU
ROSSIN, RAFFAELLA
ROBILLARD, MARC STEFAN
LUB, JOHAN
description Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels- Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has a flattened structure as a result of the position of at least two exocyclic bonds.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene
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