Methods for synthesizing molybdopterin precursor Z derivatives

Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates...

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Hauptverfasser: DAI, DANMEI, BRUNNER, ANDREAS, DIXON, RACHEL ANNE, LITTLE, GILLIAN MARY, WATT, DEREK KEVIN, BAARS, SYLVIA MYRNA, LONG, XIANGTIAN, LANDREAU, CYRILLE ABEL SEBASTIEN, CLINCH, KEITH, PROISY, NICOLAS GEORGES RENE
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creator DAI, DANMEI
BRUNNER, ANDREAS
DIXON, RACHEL ANNE
LITTLE, GILLIAN MARY
WATT, DEREK KEVIN
BAARS, SYLVIA MYRNA
LONG, XIANGTIAN
LANDREAU, CYRILLE ABEL SEBASTIEN
CLINCH, KEITH
PROISY, NICOLAS GEORGES RENE
description Provided herein are synthetic methods for preparing a compound of formula (I): Also provided herein are synthetic methods for preparing a compound of formula (XIII): The disclosure also provides useful intermediates, derivatives, prodrugs, and pharmaceutically acceptable salts, solvates and hydrates of the formula (I) and formula (XIII) compounds. These compounds are useful for treating diseases associated with molybdenum cofactor deficiency.
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subjects AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
title Methods for synthesizing molybdopterin precursor Z derivatives
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