Novel amide derivative and use thereof as medicine

Provided is a novel low molecular weight compound which inhibits the production of inducible MMPs, in particular MMP-9, rather than the production of constitutive MMP-2. Also provided is a prophylactic and/or therapeutic agent for an autoimmune disease or arthrosis deformans. An amide derivative rep...

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Hauptverfasser: Maeda, Kazuhiro, Ishibuchi, Seigo, Tashiro, Kaoru, Tarao, Akiko, Endoh, Jun-ichi, Hikawa, Hidemasa
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creator Maeda, Kazuhiro
Ishibuchi, Seigo
Tashiro, Kaoru
Tarao, Akiko
Endoh, Jun-ichi
Hikawa, Hidemasa
description Provided is a novel low molecular weight compound which inhibits the production of inducible MMPs, in particular MMP-9, rather than the production of constitutive MMP-2. Also provided is a prophylactic and/or therapeutic agent for an autoimmune disease or arthrosis deformans. An amide derivative represented by formula (I) [wherein each symbol is as defined in the specification], or a pharmacologically acceptable salt thereof.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Novel amide derivative and use thereof as medicine
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