6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists
6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1 H BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS Abstract Rr R R 4 R N-R 3 (I) The present invention provides 6-substituted 2,3,4,5-tetrahydro- 1 H benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders in...
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| creator | SIEDEM, CHRISTOPHER STEPHEN BRINER, KARIN RODRIGUEZ, MICHAEL JOHN SINGH, AJAY MAZANETZ, MICHAEL PHILIP ALLEN, JOHN GORDON COHEN, MICHAEL PHILIP REINHARD, MATTHEW ROBERT TIDWELL, MICHAEL WADE BOYD, STEVEN ARMEN LEE, WAI-MAN CONWAY, RICHARD GERARD HELLMAN, SARAH LYNNE GALKA, CHRISTOPHER STANLEY ROTHHAAR, ROGER RYAN WILLIAMS, ANDREW CAERWYN DEO, ARUNDHATI S ZHANG, DEYI VICTOR, FRANTZ MARTINEZ-GRAU, MARIA ANGELES |
| description | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1 H BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS Abstract Rr R R 4 R N-R 3 (I) The present invention provides 6-substituted 2,3,4,5-tetrahydro- 1 H benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: I where R is -C= C-R'0 , -O-R , -S-R' 4 , or NR 24R ; and other substituents are as defined in the specification. (5273342_l):KZA |
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| title | 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists |
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