Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same

The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl; R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl; R3 stands for halogen, C1-6 alkyl or O-R', where R...

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Hauptverfasser: KEPPLER, ARTUR FRANZ, ZAIM, MARCIO HENRIQUE, SACURAI, SERGIO LUIZ, TOUZARIM, CARLOS EDUARDO DA COSTA
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ZAIM, MARCIO HENRIQUE
SACURAI, SERGIO LUIZ
TOUZARIM, CARLOS EDUARDO DA COSTA
description The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl; R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl; R3 stands for halogen, C1-6 alkyl or O-R', where R' stands for hydrogen or lower alkyls; R6 stands for aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R', where R' stands for hydrogen or lower alkyls, the aryl substituents being a halogen or a tetrazolyl radical; n and m independently equal an integer from 0 to 5, provided that, when Ar stands for imidazolyl, R3 for chlorine, R6 for p-phenyl and R1, R2, R4 and R5 for hydrogen, n is different from 2. When n and m differ from 0 and 1, R3 or R6 may represent optionally different substituents. The present invention also relates to the pharmaceutically acceptable salts, solvates, pro-drugs, esters, enantiomers and/or diastereoisomers thereof, or mixtures thereof, to the methods for preparing said compounds, to intermediate compounds, to pharmaceutical compositions comprising said compounds and/or derivatives, to medicaments comprising said compounds and/or derivatives, as well as to the uses of and methods using said compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by micro-organisms such as fungi, bacteria and/or protozoa, for inhibiting the proliferation and/or survival of said micro-organisms, for treating and/or preventing micro-organism growth on an individual, and for producing a medicament.
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The present invention also relates to the pharmaceutically acceptable salts, solvates, pro-drugs, esters, enantiomers and/or diastereoisomers thereof, or mixtures thereof, to the methods for preparing said compounds, to intermediate compounds, to pharmaceutical compositions comprising said compounds and/or derivatives, to medicaments comprising said compounds and/or derivatives, as well as to the uses of and methods using said compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by micro-organisms such as fungi, bacteria and/or protozoa, for inhibiting the proliferation and/or survival of said micro-organisms, for treating and/or preventing micro-organism growth on an individual, and for producing a medicament.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150212&amp;DB=EPODOC&amp;CC=AU&amp;NR=2010286266B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20150212&amp;DB=EPODOC&amp;CC=AU&amp;NR=2010286266B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KEPPLER, ARTUR FRANZ</creatorcontrib><creatorcontrib>ZAIM, MARCIO HENRIQUE</creatorcontrib><creatorcontrib>SACURAI, SERGIO LUIZ</creatorcontrib><creatorcontrib>TOUZARIM, CARLOS EDUARDO DA COSTA</creatorcontrib><title>Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same</title><description>The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl; R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl; R3 stands for halogen, C1-6 alkyl or O-R', where R' stands for hydrogen or lower alkyls; R6 stands for aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R', where R' stands for hydrogen or lower alkyls, the aryl substituents being a halogen or a tetrazolyl radical; n and m independently equal an integer from 0 to 5, provided that, when Ar stands for imidazolyl, R3 for chlorine, R6 for p-phenyl and R1, R2, R4 and R5 for hydrogen, n is different from 2. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same
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