Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, =CH-, -CH

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Hauptverfasser: HOENKE, CHRISTOPH, EBEL, HEINER, TRIESELMANN, THOMAS, SCHEUERER, STEFAN, FRATTINI, SARA, HOBBIE, SILKE (MARIE KATRIN), BUETTNER, FRANK, TIELMANN, PATRICK, GIOVANNINI, RICCARDO
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creator HOENKE, CHRISTOPH
EBEL, HEINER
TRIESELMANN, THOMAS
SCHEUERER, STEFAN
FRATTINI, SARA
HOBBIE, SILKE (MARIE KATRIN)
BUETTNER, FRANK
TIELMANN, PATRICK
GIOVANNINI, RICCARDO
description The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, =CH-, -CH
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD
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