Process for the manufacture of an indolinone derivative

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoet...

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Hauptverfasser:	SCHIFFERS, ROBERT, SCHMID, ROLF, SCHNAUBELT, JUERGEN, RALL, WERNER, MERTEN, JOERN, LINZ, GUENTER, REICHEL, CARSTEN, RENNER, SVENJA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	SCHIFFERS, ROBERT SCHMID, ROLF SCHNAUBELT, JUERGEN RALL, WERNER MERTEN, JOERN LINZ, GUENTER REICHEL, CARSTEN RENNER, SVENJA
description	The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	Process for the manufacture of an indolinone derivative
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