Macrocyclic compounds as antiviral agents
A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of...
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| creator | STEVEN HARPER VINCENZO SUMMA MICHAEL RUDD MARCELLOFILIPPO JOHN BUTCHER JOHN MCCAULEY MARCO FERRARA NIGEL LIVERTON JOSEPH J. ROMANO MARIA EMILIAFRANCESCO |
| description | A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I): |
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ROMANO ; MARIA EMILIAFRANCESCO</creator><creatorcontrib>STEVEN HARPER ; VINCENZO SUMMA ; MICHAEL RUDD ; MARCELLOFILIPPO ; JOHN BUTCHER ; JOHN MCCAULEY ; MARCO FERRARA ; NIGEL LIVERTON ; JOSEPH J. ROMANO ; MARIA EMILIAFRANCESCO</creatorcontrib><description>A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):</description><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090122&DB=EPODOC&CC=AU&NR=2008277377A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20090122&DB=EPODOC&CC=AU&NR=2008277377A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STEVEN HARPER</creatorcontrib><creatorcontrib>VINCENZO SUMMA</creatorcontrib><creatorcontrib>MICHAEL RUDD</creatorcontrib><creatorcontrib>MARCELLOFILIPPO</creatorcontrib><creatorcontrib>JOHN BUTCHER</creatorcontrib><creatorcontrib>JOHN MCCAULEY</creatorcontrib><creatorcontrib>MARCO FERRARA</creatorcontrib><creatorcontrib>NIGEL LIVERTON</creatorcontrib><creatorcontrib>JOSEPH J. 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ROMANO ; MARIA EMILIAFRANCESCO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2008277377A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>STEVEN HARPER</creatorcontrib><creatorcontrib>VINCENZO SUMMA</creatorcontrib><creatorcontrib>MICHAEL RUDD</creatorcontrib><creatorcontrib>MARCELLOFILIPPO</creatorcontrib><creatorcontrib>JOHN BUTCHER</creatorcontrib><creatorcontrib>JOHN MCCAULEY</creatorcontrib><creatorcontrib>MARCO FERRARA</creatorcontrib><creatorcontrib>NIGEL LIVERTON</creatorcontrib><creatorcontrib>JOSEPH J. ROMANO</creatorcontrib><creatorcontrib>MARIA EMILIAFRANCESCO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STEVEN HARPER</au><au>VINCENZO SUMMA</au><au>MICHAEL RUDD</au><au>MARCELLOFILIPPO</au><au>JOHN BUTCHER</au><au>JOHN MCCAULEY</au><au>MARCO FERRARA</au><au>NIGEL LIVERTON</au><au>JOSEPH J. ROMANO</au><au>MARIA EMILIAFRANCESCO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Macrocyclic compounds as antiviral agents</title><date>2009-01-22</date><risdate>2009</risdate><abstract>A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Macrocyclic compounds as antiviral agents |
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