Pim kinase inhibitors and methods of their use

New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine...

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Hauptverfasser:	CORNELIA BELLAMACINA, PABLO GARCIA, MIKA LINDVALL, JIONG LAN, TATIANA ZAVOROTINSKAYA, KAY HUH, WILLIAM ANTONIOS-MCCREA JR, MATTHEW BURGER, CYNTHIA SHAFER, CHRISTOPHER MCBRIDE, WOOSEOK HAN, GISELE NISHIGUCHI, GORDANA ATALLAH, ANNETTE WALTER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.