Novel compound having affinity for amyloid
Disclosed is a compound having affinity for amyloid and satisfactorily rapid clearance from a normal tissue and reduced in toxicity including mutagenicity. Specifically disclosed are: a compound represented by the formula (1) and a salt thereof; and a low-toxic diagnostic agent for Alzheimer's...
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| creator | BOUVET, DENIS RAYMOND CHRISTOPHE STOREY, ANTHONY EAMON NAKAMURA, DAISAKU TANIFUJI, SHIGEYUKI HAYASHI, AKIO TAKASAKI, SHINYA |
| description | Disclosed is a compound having affinity for amyloid and satisfactorily rapid clearance from a normal tissue and reduced in toxicity including mutagenicity. Specifically disclosed are: a compound represented by the formula (1) and a salt thereof; and a low-toxic diagnostic agent for Alzheimer's disease comprising the compound or the salt thereof. (1) wherein R represents a group selected from a hydrogen, a hydroxyl group, a carboxyl group, a sulfate group, an amino group, a nitro group, a cyano group, an alkyl substituent group having 1 to 4 carbon atoms and an alkoxy substituent group having 1 to 4 carbon atoms; R represents a radioactive halogen substituent group; and m represents an integer ranging from 0 to 2. |
| format | Patent |
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Specifically disclosed are: a compound represented by the formula (1) and a salt thereof; and a low-toxic diagnostic agent for Alzheimer's disease comprising the compound or the salt thereof. (1) wherein R represents a group selected from a hydrogen, a hydroxyl group, a carboxyl group, a sulfate group, an amino group, a nitro group, a cyano group, an alkyl substituent group having 1 to 4 carbon atoms and an alkoxy substituent group having 1 to 4 carbon atoms; R represents a radioactive halogen substituent group; and m represents an integer ranging from 0 to 2.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEASUREMENT OF NUCLEAR OR X-RADIATION ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; TESTING</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120419&DB=EPODOC&CC=AU&NR=2007261985B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120419&DB=EPODOC&CC=AU&NR=2007261985B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOUVET, DENIS RAYMOND CHRISTOPHE</creatorcontrib><creatorcontrib>STOREY, ANTHONY EAMON</creatorcontrib><creatorcontrib>NAKAMURA, DAISAKU</creatorcontrib><creatorcontrib>TANIFUJI, SHIGEYUKI</creatorcontrib><creatorcontrib>HAYASHI, AKIO</creatorcontrib><creatorcontrib>TAKASAKI, SHINYA</creatorcontrib><title>Novel compound having affinity for amyloid</title><description>Disclosed is a compound having affinity for amyloid and satisfactorily rapid clearance from a normal tissue and reduced in toxicity including mutagenicity. 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Specifically disclosed are: a compound represented by the formula (1) and a salt thereof; and a low-toxic diagnostic agent for Alzheimer's disease comprising the compound or the salt thereof. (1) wherein R represents a group selected from a hydrogen, a hydroxyl group, a carboxyl group, a sulfate group, an amino group, a nitro group, a cyano group, an alkyl substituent group having 1 to 4 carbon atoms and an alkoxy substituent group having 1 to 4 carbon atoms; R represents a radioactive halogen substituent group; and m represents an integer ranging from 0 to 2.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEASUREMENT OF NUCLEAR OR X-RADIATION MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING |
| title | Novel compound having affinity for amyloid |
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