Peptidomimetic protease inhibitors
Peptidomimetic Protease Inhibitors Abstract The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis 5 C NS3 protease inhibitors; intermediates thereto; their preparation including novel...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GARCIA-PAREDES, CRISTINA SNYDER, NANCY JUNE LAMAR, JASON ERIC SUN, XICHENG DAVID WANG, Q. MAY YIP, YVONNE YEE MAI GLASS, JOHN IRVIN COLLADO, IVAN TEBBE, MARK JOSEPH BABINE, ROBERT EDWARD CHEN, SHU HUI PARKER III, RAYMOND SAMUEL GUO, DEQI JIN, LING VICTOR, FRANTZ |
| description | Peptidomimetic Protease Inhibitors Abstract The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis 5 C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in 1o addition to one or more HCV seine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU2007240156CC1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU2007240156CC1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU2007240156CC13</originalsourceid><addsrcrecordid>eNrjZFAKSC0oyUzJz83MTS3JTFYoKMovSU0sTlXIzMvITMosyS8q5mFgTUvMKU7lhdLcDCpuriHOHrqpBfnxqcUFicmpeakl8Y6hRgYG5kYmBoamZs7OhsZEKgMA2Mgn9g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Peptidomimetic protease inhibitors</title><source>esp@cenet</source><creator>GARCIA-PAREDES, CRISTINA ; SNYDER, NANCY JUNE ; LAMAR, JASON ERIC ; SUN, XICHENG DAVID ; WANG, Q. MAY ; YIP, YVONNE YEE MAI ; GLASS, JOHN IRVIN ; COLLADO, IVAN ; TEBBE, MARK JOSEPH ; BABINE, ROBERT EDWARD ; CHEN, SHU HUI ; PARKER III, RAYMOND SAMUEL ; GUO, DEQI ; JIN, LING ; VICTOR, FRANTZ</creator><creatorcontrib>GARCIA-PAREDES, CRISTINA ; SNYDER, NANCY JUNE ; LAMAR, JASON ERIC ; SUN, XICHENG DAVID ; WANG, Q. MAY ; YIP, YVONNE YEE MAI ; GLASS, JOHN IRVIN ; COLLADO, IVAN ; TEBBE, MARK JOSEPH ; BABINE, ROBERT EDWARD ; CHEN, SHU HUI ; PARKER III, RAYMOND SAMUEL ; GUO, DEQI ; JIN, LING ; VICTOR, FRANTZ</creatorcontrib><description>Peptidomimetic Protease Inhibitors Abstract The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis 5 C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in 1o addition to one or more HCV seine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140116&DB=EPODOC&CC=AU&NR=2007240156C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140116&DB=EPODOC&CC=AU&NR=2007240156C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GARCIA-PAREDES, CRISTINA</creatorcontrib><creatorcontrib>SNYDER, NANCY JUNE</creatorcontrib><creatorcontrib>LAMAR, JASON ERIC</creatorcontrib><creatorcontrib>SUN, XICHENG DAVID</creatorcontrib><creatorcontrib>WANG, Q. MAY</creatorcontrib><creatorcontrib>YIP, YVONNE YEE MAI</creatorcontrib><creatorcontrib>GLASS, JOHN IRVIN</creatorcontrib><creatorcontrib>COLLADO, IVAN</creatorcontrib><creatorcontrib>TEBBE, MARK JOSEPH</creatorcontrib><creatorcontrib>BABINE, ROBERT EDWARD</creatorcontrib><creatorcontrib>CHEN, SHU HUI</creatorcontrib><creatorcontrib>PARKER III, RAYMOND SAMUEL</creatorcontrib><creatorcontrib>GUO, DEQI</creatorcontrib><creatorcontrib>JIN, LING</creatorcontrib><creatorcontrib>VICTOR, FRANTZ</creatorcontrib><title>Peptidomimetic protease inhibitors</title><description>Peptidomimetic Protease Inhibitors Abstract The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis 5 C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in 1o addition to one or more HCV seine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAKSC0oyUzJz83MTS3JTFYoKMovSU0sTlXIzMvITMosyS8q5mFgTUvMKU7lhdLcDCpuriHOHrqpBfnxqcUFicmpeakl8Y6hRgYG5kYmBoamZs7OhsZEKgMA2Mgn9g</recordid><startdate>20140116</startdate><enddate>20140116</enddate><creator>GARCIA-PAREDES, CRISTINA</creator><creator>SNYDER, NANCY JUNE</creator><creator>LAMAR, JASON ERIC</creator><creator>SUN, XICHENG DAVID</creator><creator>WANG, Q. MAY</creator><creator>YIP, YVONNE YEE MAI</creator><creator>GLASS, JOHN IRVIN</creator><creator>COLLADO, IVAN</creator><creator>TEBBE, MARK JOSEPH</creator><creator>BABINE, ROBERT EDWARD</creator><creator>CHEN, SHU HUI</creator><creator>PARKER III, RAYMOND SAMUEL</creator><creator>GUO, DEQI</creator><creator>JIN, LING</creator><creator>VICTOR, FRANTZ</creator><scope>EVB</scope></search><sort><creationdate>20140116</creationdate><title>Peptidomimetic protease inhibitors</title><author>GARCIA-PAREDES, CRISTINA ; SNYDER, NANCY JUNE ; LAMAR, JASON ERIC ; SUN, XICHENG DAVID ; WANG, Q. MAY ; YIP, YVONNE YEE MAI ; GLASS, JOHN IRVIN ; COLLADO, IVAN ; TEBBE, MARK JOSEPH ; BABINE, ROBERT EDWARD ; CHEN, SHU HUI ; PARKER III, RAYMOND SAMUEL ; GUO, DEQI ; JIN, LING ; VICTOR, FRANTZ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2007240156CC13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2014</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GARCIA-PAREDES, CRISTINA</creatorcontrib><creatorcontrib>SNYDER, NANCY JUNE</creatorcontrib><creatorcontrib>LAMAR, JASON ERIC</creatorcontrib><creatorcontrib>SUN, XICHENG DAVID</creatorcontrib><creatorcontrib>WANG, Q. MAY</creatorcontrib><creatorcontrib>YIP, YVONNE YEE MAI</creatorcontrib><creatorcontrib>GLASS, JOHN IRVIN</creatorcontrib><creatorcontrib>COLLADO, IVAN</creatorcontrib><creatorcontrib>TEBBE, MARK JOSEPH</creatorcontrib><creatorcontrib>BABINE, ROBERT EDWARD</creatorcontrib><creatorcontrib>CHEN, SHU HUI</creatorcontrib><creatorcontrib>PARKER III, RAYMOND SAMUEL</creatorcontrib><creatorcontrib>GUO, DEQI</creatorcontrib><creatorcontrib>JIN, LING</creatorcontrib><creatorcontrib>VICTOR, FRANTZ</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GARCIA-PAREDES, CRISTINA</au><au>SNYDER, NANCY JUNE</au><au>LAMAR, JASON ERIC</au><au>SUN, XICHENG DAVID</au><au>WANG, Q. MAY</au><au>YIP, YVONNE YEE MAI</au><au>GLASS, JOHN IRVIN</au><au>COLLADO, IVAN</au><au>TEBBE, MARK JOSEPH</au><au>BABINE, ROBERT EDWARD</au><au>CHEN, SHU HUI</au><au>PARKER III, RAYMOND SAMUEL</au><au>GUO, DEQI</au><au>JIN, LING</au><au>VICTOR, FRANTZ</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Peptidomimetic protease inhibitors</title><date>2014-01-16</date><risdate>2014</risdate><abstract>Peptidomimetic Protease Inhibitors Abstract The present invention relates to peptidomimetic compounds useful as protease inhibitors (1), particularly as serine protease inhibitors and more particularly as hepatitis 5 C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in 1o addition to one or more HCV seine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_AU2007240156CC1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Peptidomimetic protease inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T14%3A36%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GARCIA-PAREDES,%20CRISTINA&rft.date=2014-01-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2007240156CC1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |