Interleukin-15 antagonist peptide

The invention relates to the field of molecular pharmacology and, in particular, to a peptide belonging to the Interleukin-15 (IL-15) sequence, which can inhibit the biological activity of said molecule and analogues or mimetics of the peptide. The invention demonstrates that, when bound to the alph...

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Bibliographische Detailangaben
Hauptverfasser:	SANTOS SAVIO, ALICIA, ARRIETA AGUERO, CELIA AURORA, CABRALES RICO, ANIA, PEREA RODRIGUEZ, SILVIO ERNESTO, GERONIMO PEREZ, HAYDEE, REYES ACOSTA, OSVALDO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the field of molecular pharmacology and, in particular, to a peptide belonging to the Interleukin-15 (IL-15) sequence, which can inhibit the biological activity of said molecule and analogues or mimetics of the peptide. The invention demonstrates that, when bound to the alpha subunit of the receptor (IL-15R), the peptide inhibits T-cell proliferation induced by IL-15 and apoptosis caused by TNF. The invention also relates to the use of the peptide in the treatment of pathologies in which the abnormal IL-15 or IL-15R expression is related to the course of the disease.