Interleukin-15 antagonist peptide

Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both...

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Hauptverfasser: HAYDEE GERONIMO PEREZ, ANIA CABRALES RICO, ALICIA SANTOS SAVIO, CELIA AURORA ARRIETA AGUERO, SILVIO ERNESTO PEREA RODRIGUEZ, OSVALDO REYES ACOSTA
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creator HAYDEE GERONIMO PEREZ
ANIA CABRALES RICO
ALICIA SANTOS SAVIO
CELIA AURORA ARRIETA AGUERO
SILVIO ERNESTO PEREA RODRIGUEZ
OSVALDO REYES ACOSTA
description Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis. Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
title Interleukin-15 antagonist peptide
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