Heteroaryl piperidine glycine transporter inhibitors
The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunct...
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| creator | HARTMAN, GEORGE D WOLKENBERG, SCOTT E WANG, YI HALLETT, DAVID BLACKABY, WESLEY LEWIS, RICHARD T NAYLOR, ELIZABETH JENNINGS, ANDREW S DUGGAN, MARK E LEISTER, WILLIAM H LINDSLEY, CRAIG W WISNOSKI, DAVID D ZHAO, ZHIJIAN STREET, LESLIE J |
| description | The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Heteroaryl piperidine glycine transporter inhibitors |
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