Improved process for the preparation of 9,11 epoxy steroids

Improved process for the preparation of 9,11 epoxy steroids

Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presenc...

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Hauptverfasser: CHUNG C. KIM, KEITH D. MAISTO, JOSEPH J. WIECZOREK, PAUL DAVID, MARLON V. CARLOS
Format: Patent
Sprache:eng
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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creator CHUNG C. KIM
KEITH D. MAISTO
JOSEPH J. WIECZOREK
PAUL DAVID
MARLON V. CARLOS
description Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presence of a peroxide activator. The epoxidation processes described are conducted at relatively low hydrogen peroxide to steroid substrate ratio. Several optional process modifications are described.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
title Improved process for the preparation of 9,11 epoxy steroids
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