Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors
Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the preven...
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| creator | BOYOUNG KIM TERRY A. LYLE JOHN S. WAI MELISSA EGBERTSON LEKHANH O. TRAN LINGHANG ZHUANG KELLY L. SAVAGE CATHERINE M. WISCOUNT THORSTEN E. FISHER MARK W. EMBREY DONNETTE D. STAAS |
| description | Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. |
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STAAS</creator><creatorcontrib>BOYOUNG KIM ; TERRY A. LYLE ; JOHN S. WAI ; MELISSA EGBERTSON ; LEKHANH O. TRAN ; LINGHANG ZHUANG ; KELLY L. SAVAGE ; CATHERINE M. WISCOUNT ; THORSTEN E. FISHER ; MARK W. EMBREY ; DONNETTE D. STAAS</creatorcontrib><description>Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</description><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; FISHING ; FORESTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HUNTING ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; TRAPPING</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050512&DB=EPODOC&CC=AU&NR=2004285449A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050512&DB=EPODOC&CC=AU&NR=2004285449A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOYOUNG KIM</creatorcontrib><creatorcontrib>TERRY A. LYLE</creatorcontrib><creatorcontrib>JOHN S. WAI</creatorcontrib><creatorcontrib>MELISSA EGBERTSON</creatorcontrib><creatorcontrib>LEKHANH O. TRAN</creatorcontrib><creatorcontrib>LINGHANG ZHUANG</creatorcontrib><creatorcontrib>KELLY L. SAVAGE</creatorcontrib><creatorcontrib>CATHERINE M. WISCOUNT</creatorcontrib><creatorcontrib>THORSTEN E. FISHER</creatorcontrib><creatorcontrib>MARK W. EMBREY</creatorcontrib><creatorcontrib>DONNETTE D. STAAS</creatorcontrib><title>Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors</title><description>Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>TRAPPING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAjwqEwpyq-oVCioLMpMyQeSRfk5ICqxKjMvVSElMx9IJufnFuSX5qUUK5QWp6aV5igkFit4eIYpZOaVpKYXJRanAlkZmUmZJflFxTwMrGmJOcWpvFCam0HZzTXE2UM3tSA_PrW4IDE5NS-1JN4x1MjAwMTIwtTExNLR0Jg4VQAqTDld</recordid><startdate>20050512</startdate><enddate>20050512</enddate><creator>BOYOUNG KIM</creator><creator>TERRY A. 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LYLE</creatorcontrib><creatorcontrib>JOHN S. WAI</creatorcontrib><creatorcontrib>MELISSA EGBERTSON</creatorcontrib><creatorcontrib>LEKHANH O. TRAN</creatorcontrib><creatorcontrib>LINGHANG ZHUANG</creatorcontrib><creatorcontrib>KELLY L. SAVAGE</creatorcontrib><creatorcontrib>CATHERINE M. WISCOUNT</creatorcontrib><creatorcontrib>THORSTEN E. FISHER</creatorcontrib><creatorcontrib>MARK W. EMBREY</creatorcontrib><creatorcontrib>DONNETTE D. STAAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOYOUNG KIM</au><au>TERRY A. LYLE</au><au>JOHN S. WAI</au><au>MELISSA EGBERTSON</au><au>LEKHANH O. TRAN</au><au>LINGHANG ZHUANG</au><au>KELLY L. SAVAGE</au><au>CATHERINE M. WISCOUNT</au><au>THORSTEN E. FISHER</au><au>MARK W. EMBREY</au><au>DONNETTE D. STAAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors</title><date>2005-05-12</date><risdate>2005</risdate><abstract>Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING |
| title | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors |
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