2,4 di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or Syk inhibitors

2,4 di (hetero) -arylamino-pyrimidine derivatives as ZAP-70 and/or Syk inhibitors

Disclosed are pyrimidine derivatives of formula wherein R 0 , R 1 , R 3 to R 9 , and Z have a signification as indicated in claim 1, which have ZAP-70 and/or Syk inhibitory activities.

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Bibliographische Detailangaben
Hauptverfasser: ANETTE VON MATT, GEBHARD THOMA, RUDOLF DUTHALER, GERHARD ZENKE, LOUIS WALLISER, NIGEL GRAHAM COOKE, ROLF BAENTELI, MAURICE VAN EIS, PETER BUEHLMAYER, MARIE CLAUDE BERNHARD, KLAUS HINTERDING
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed are pyrimidine derivatives of formula wherein R 0 , R 1 , R 3 to R 9 , and Z have a signification as indicated in claim 1, which have ZAP-70 and/or Syk inhibitory activities.