Modulation of the poliovirus receptor function

A molecule specifically binding to at least one intra- or extracellular domain of the CD155 (cluster of differentiation 155), the poliovirus receptor (PVR), or any of their derivatives, where the molecule has the ability to modulate a receptor mediated adhesion, trafficking and/or invasion behavior...

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Hauptverfasser: CAROLIN ZEHETMEIER, CHRISTINE MARGARETE UNGER, GERALD BESTE, BRENDA K. EUSTACE, DANIEL G. JAY, KEVIN ERNEST SLOAN, CLAUDIA TORELLA, BLANCA LAIN
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creator CAROLIN ZEHETMEIER
CHRISTINE MARGARETE UNGER
GERALD BESTE
BRENDA K. EUSTACE
DANIEL G. JAY
KEVIN ERNEST SLOAN
CLAUDIA TORELLA
BLANCA LAIN
description A molecule specifically binding to at least one intra- or extracellular domain of the CD155 (cluster of differentiation 155), the poliovirus receptor (PVR), or any of their derivatives, where the molecule has the ability to modulate a receptor mediated adhesion, trafficking and/or invasion behavior of a cell expressing the CD155, the PVR, or any derivatives, is new. Independent claims are also included for the following: (1) a method of identifying and isolating the above molecule; (2) a nucleic acid molecule encoding the molecule cited above, or the ligand identified by the above method; (3) a vector comprising the above nucleic acid molecule; (4) a pharmaceutical composition comprising the above molecule, the molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and/or a pharmaceutical carrier and/or diluent; (5) methods of modulating ex vivo the adhesion or invasion behavior of a cell expressing CD155, PVR or any of their derivatives; (6) a method of treating or preventing proliferative disorder or disease, cancer and/or metastasis; (7) a kit comprising the above molecule, molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and suitable testing containers; and (8) a method of detecting and/or isolating cells expressing CD155, PVR or any derivatives. ACTIVITY : Cytostatic. No biological data given. MECHANISM OF ACTION : Gene therapy.
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Independent claims are also included for the following: (1) a method of identifying and isolating the above molecule; (2) a nucleic acid molecule encoding the molecule cited above, or the ligand identified by the above method; (3) a vector comprising the above nucleic acid molecule; (4) a pharmaceutical composition comprising the above molecule, the molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and/or a pharmaceutical carrier and/or diluent; (5) methods of modulating ex vivo the adhesion or invasion behavior of a cell expressing CD155, PVR or any of their derivatives; (6) a method of treating or preventing proliferative disorder or disease, cancer and/or metastasis; (7) a kit comprising the above molecule, molecules or ligands identified by the above method, the nucleic acid molecule or the vector, and suitable testing containers; and (8) a method of detecting and/or isolating cells expressing CD155, PVR or any derivatives. 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language eng
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
title Modulation of the poliovirus receptor function
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