Method of manufacture of 1,3-oxathiolane nucleosides

Method of manufacture of 1,3-oxathiolane nucleosides

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be pro...

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Hauptverfasser: MERRICK ALMOND, GEORGE R. PAINTER, MARCOS LUIS SZNAIDMAN, JOSE SORIA, DENNIS C. LIOTTA, DARRYL CLEARY
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator MERRICK ALMOND
GEORGE R. PAINTER
MARCOS LUIS SZNAIDMAN
JOSE SORIA
DENNIS C. LIOTTA
DARRYL CLEARY
description Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Method of manufacture of 1,3-oxathiolane nucleosides
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