KINASE MODULATORS
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regul...
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| creator | ERICK, WANG CO MOON, HWAN KIM AMY LEW WEI XU ZHAOYANG WEN LYNNE, CANNE BANNEN JOHN, M. NUSS JASON, JEVIOUS PARKS S., DAVID BROWN RHETT, RONALD KLEIN WEI CHENG MORRISON, B. MAC DONNA, T. LE |
| description | The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. |
| format | Patent |
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More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040623&DB=EPODOC&CC=AU&NR=2003302665A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040623&DB=EPODOC&CC=AU&NR=2003302665A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ERICK, WANG CO</creatorcontrib><creatorcontrib>MOON, HWAN KIM</creatorcontrib><creatorcontrib>AMY LEW</creatorcontrib><creatorcontrib>WEI XU</creatorcontrib><creatorcontrib>ZHAOYANG WEN</creatorcontrib><creatorcontrib>LYNNE, CANNE BANNEN</creatorcontrib><creatorcontrib>JOHN, M. 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NUSS</creatorcontrib><creatorcontrib>JASON, JEVIOUS PARKS</creatorcontrib><creatorcontrib>S., DAVID BROWN</creatorcontrib><creatorcontrib>RHETT, RONALD KLEIN</creatorcontrib><creatorcontrib>WEI CHENG</creatorcontrib><creatorcontrib>MORRISON, B. MAC</creatorcontrib><creatorcontrib>DONNA, T. LE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ERICK, WANG CO</au><au>MOON, HWAN KIM</au><au>AMY LEW</au><au>WEI XU</au><au>ZHAOYANG WEN</au><au>LYNNE, CANNE BANNEN</au><au>JOHN, M. NUSS</au><au>JASON, JEVIOUS PARKS</au><au>S., DAVID BROWN</au><au>RHETT, RONALD KLEIN</au><au>WEI CHENG</au><au>MORRISON, B. MAC</au><au>DONNA, T. LE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>KINASE MODULATORS</title><date>2004-06-23</date><risdate>2004</risdate><abstract>The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | KINASE MODULATORS |
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