GENETIC COMPUTING USING COMBINATORIAL TRANSCRIPTION CONTROL

A scheme is provided for selecting the regulatory DNA sequences to exert combinatorial control of gene transcription in vivo by multiple regulatory proteins, i.e., transcription factors (TFs). The method provides the ability to implement a wide range of complex logic functions through the manipulati...

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Bibliographische Detailangaben
Hauptverfasser:	TERENCE, TAI-LI HWA, NICOLAS BUCHLER, ULRICH GERLAND
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS COMPUTING COUNTING CULTURE MEDIA ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A scheme is provided for selecting the regulatory DNA sequences to exert combinatorial control of gene transcription in vivo by multiple regulatory proteins, i.e., transcription factors (TFs). The method provides the ability to implement a wide range of complex logic functions through the manipulation of the regulatory DNA sequences, typically several hundred bases in length. The method includes procedures for selecting the strengths of the binding sites of different TFs and their relative positioning in order to implement a plurality of different logic functions.